As a fundamental problem in machine learning, dataset shift induces a paradigm to learn and transfer knowledge under changing environment. Previous methods assume the changes are induced by covariate, which is less practical for complex real-world data. We consider the Generalized Label Shift (GLS), which provides an interpretable insight into the learning and transfer of desirable knowledge. Current GLS methods: 1) are not well-connected with the statistical learning theory; 2) usually assume the shifting conditional distributions will be matched with an implicit transformation, but its explicit modeling is unexplored. In this paper, we propose a conditional adaptation framework to deal with these challenges.